3D Cell Culture Market at a CAGR of 25.4% | Type, Application, End User, Region, Key Players

3D Cell Culture Market: by Type (Hydrogel, ECM, Hanging Drop, Bioreactor, Microfluidics, Magnetic Levitation), Application (Cancer, Stem Cell, Toxicology, Tissue Engineering), End User (Pharma, Biotech, Research, Cosmetics), and region (North America, Europe, Asia-Pacific, Middle East, and Africa and South America). The global 3D Cell Culture Market size is projected to reach a CAGR of 25.4% from 2023-2030.

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3D Cell Culture Market Competitive Landscape:

Merck KGaA
Thermo Fisher Scientific, Inc.
PromoCell GmbH
Greiner Bio One International GmbH
Corning, Inc.
3D Biomatrix
Lonza
Avantor Performance Materials, LLC
Tecan Trading AG
3D Biotek LLC
Global Cell Solutions, Inc.
InSphero

In July 2021, Lonza Group AG (Switzerland) and CN Bio Innovations (UK) announced a distribution agreement providing pre-validated hepatocytes for use on CN Bio's innovative PhysioMimix Organ-On-a-Chip (OOC) range of single and multi-organ micro physiological systems (MPS).

In March 2021, Thermo Fisher Scientific Inc. (US) planned to spend around USD 600 million on expanding its bioprocessing production capabilities in the Americas, Europe, and Asia.

3D Cell Culture Market Key Findings

The technology segment is further fragmented into Scaffold-based 3D Cell Cultures, Scaffold-free 3D Cell Cultures, and Bioreactors. Scaffold-based technology accounted for the largest revenue share. The use of hydrogels as scaffolds in 3-dimensional cell culture-based research enables the incorporation of sophisticated biochemical and mechanical signs as a mirror of the native extracellular matrix. Moreover, the launch of novel products and the increasing need for advancements in hydrogels for providing robust platforms for studying human and cellular physiology are expected to boost market growth in the coming years.

The application segment is further segmented into Cancer, Tissue Engineering & Immunohistochemistry, Drug Development, Stem Cell Research, and Others. The cancer segment dominated the market with the largest revenue share. The use of spheroids as model systems during the development of anticancer therapies drives R&D in this segment. Moreover, the use of 3-dimensional cellular models for the study of cancer biology in preclinical testing and screening is expected to increase revenue generation in this segment.

The end-user segment is further fragmented into Biotechnology and Pharmaceutical Industries, Research Laboratories and Institutes, Hospitals and Diagnostic Centres, and Others. The biotechnology and pharmaceutical industries segment generated the largest revenue share. 3D cell cultures have advantages in terms of optimal oxygen and nutrient gradients, non-uniform exposure of cells within a spheroid to a drug, and realistic cell-to-cell interactions in comparison to 2D cell culture to study drug candidates. These factors make 3D cell cultures better suited for drug discovery and development, thereby driving the demand.

The market is also divided into various regions such as North America, Europe, Asia-Pacific, South America, and Middle East and Africa. North America led the global market in 2020 and accounted for the highest revenue share. The region will retain its leading position throughout the forecast period on account of the availability of private and government funding for the development of advanced 3D cell culture models, high healthcare spending, and the presence of a large number of universities and research organizations investigating various stem cell-based approaches.

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A 3D cell culture is an in-vitro technique wherein the cells can grow in an artificially created environment. These environments closely resemble the architecture and functioning of the native tissue. 3D cell culture technique helps stimulate cell differentiation, proliferation, and migration by interacting with their three-dimensional surroundings as they would in the in-vivo environment. As 3D cell cultures can mimic the structure, activity, and microenvironment of the in-vivo tissues, this technique has varied applications in the fields of drug screening, regenerative medicine, stem cell therapies, cancer research, and cell biology. The extracellular matrix in 3D cell cultures enables cell-cell communication by direct contact as in an in-vivo environment by secreting cytokines and trophic factors. These factors are changed in a 2D environment that can significantly affect the cell-cell communication, which in turn can alter cell morphology and proliferation. As 2D cultures cannot recapitulate the architecture and complex cellular matrices as in 3D cultures, this technique is gaining popularity in the healthcare research sector. In addition, 3D cell cultures can provide results with improved efficiency and reduce the cost of the overall R&D process.

The increasing product launches of 3D cell cultures by regulatory authorities and key players, respectively are expected to drive the market growth over the forecast period. The increasing R&D activities in 3D cell culture are expected to aid in the growth of the global 3D cell culture market, over the forecast period. Furthermore, the rising prevalence of cancer and infectious diseases will also dominate the market during the forecast period.

On the other hand, the lack of consistency in products such as Extracellular Matrices or Scaffolds is restraining the growth of the market globally.

The COVID-19 pandemic has resulted in nationwide lockdowns, thereby impacting every industry vertical. Likewise, the 3D cell culture market is also affected by the pandemic. The 3D cell culture industry is currently facing newer challenges to cope up with the demand and supply of 3D cell culture components owing to the COVID-19 pandemic. In addition, inconsistent and interrupted supply chain activities and the availability of human resources are expected to impact the market growth. On the contrary, the surge in research practices for developing novel therapies against COVID-19 is serving as a huge opportunity for the key market players. Research associated with stem cell therapies and regenerative medicine has shown promising results for treating the COVID-19 disease, thus, this is expected to compensate for the deleterious impact caused by lockdowns globally. Thus, the overall COVID-19 impact is anticipated to remain moderate for the prominent players in the 3D cell culture market.

North America to Dominate the Market

North America led the global market in 2021 and accounted for the highest revenue share.

The region will retain its leading position throughout the forecast period on account of the availability of private and government funding for the development of advanced 3D cell culture models, high healthcare spending, and the presence of a large number of universities and research organizations investigating various stem cell-based approaches.

Delvens Industry Expert's Standpoint

The market experiences a decline in BPS values as a result of the disadvantage of 3D cell culture against surface 2D cultures during the fluid flow procedure, making it a time-demanding and cost-incurring issue for manufacturers. In terms of macro and industry-based dynamics, the market is prone to changes as a result of medication development and regulatory impositions. In comparison to certain other cell culture methods, 3D cell culture is widely employed due to its ease and novel characteristics. 3D cell culture can be either scaffold-free or scaffold-based. Scaffolds are in charge of providing support for the cells. This market is being propelled ahead by an increased emphasis on offering options for animal testing, an increased emphasis on tailored therapy, an increase in the incidence of chronic illnesses, and an increase in the availability of research funds.

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