Press release
Advanced Merkel Cell Carcinoma Pipeline, NDA Approvals, Clinical Trials Assessment 2023 | Xencor, Inc., Incyte Corporation, Millennium Pharmaceuticals, Inc., Exelixis, and others
Advanced Merkel Cell Carcinoma Pipeline
Latest Developmental Activities in the Advanced Merkel Cell Carcinoma Treatment Landscape
• On March 22, 2023, Retifanlimab-dlwr (Zynyz, Incyte Corporation) received accelerated clearance from the Food and Drug Administration, for the treatment of adult patients with metastatic or recurrent locally advanced Merkel cell cancer (MCC).
• The approval is based on Data from the key Phase 3 KEYNOTE-091 trial, also known as EORTC-1416-LCG/ETOP-8-15 - PEARLS, served as the foundation for the approval. Disease-free survival, as determined by the investigator, was the primary effectiveness outcome measure (DFS). KEYTRUDA decreased the risk of disease recurrence or mortality by 27% in patients who underwent adjuvant platinum-based chemotherapy after surgical resection, regardless of PD-L1 expression (hazard ratio [HR]=0.73 [95% CI, 0.60-0.89]). The median DFS was nearly five years (58.7 months) for the KEYTRUDA arm and nearly three years (34.9 months) for the placebo arm in patients who underwent surgical resection and received adjuvant platinum-based chemotherapy, regardless of PD-L1 expression. This translates to a nearly two-year (23.8 months) DFS improvement over placebo. Of the 167 patients (14%) who did not receive adjuvant treatment, an exploratory subgroup analysis was conducted.
• Endometrial cancer has a robust clinical development programme at Merck. For the treatment of patients with advanced endometrial carcinoma who are pMMR, as determined by an FDA-approved test, or who are not microsatellite instability-high (MSI-H), who have disease progression after prior systemic therapy in any setting, and who are not candidates for curative surgery or radiation, Keytruda has two approved indications in the United States: in combination with LENVIMA® (lenvatinib), in collaboration with Eisai; and as a single agent.
Discover the recent breakthroughs happening in the Advanced Merkel Cell Carcinoma Pipeline landscape @ Advanced Merkel Cell Carcinoma Pipeline Outlook- https://www.delveinsight.com/report-store/advanced-merkel-cell-carcinoma-pipeline-insight?utm_source=openpr&utm_medium=pressrelease&utm_campaign=ypr
Key Takeaways from the Advanced Merkel Cell Carcinoma Pipeline Report
• DelveInsight's Advanced Merkel Cell Carcinoma pipeline report depicts a robust space with 20+ active players working to develop 20+ pipeline therapies for Advanced Merkel Cell Carcinoma treatment.
• The leading Advanced Merkel cell carcinoma Companies includes Xencor, Inc., Incyte Corporation, Millennium Pharmaceuticals, Inc., Exelixis, Bristol-Myers Squibb, bluebird bio, Affini-T Therapeutics, ImaginAb, Inc., BioInvent International AB, Ocellaris Pharma, Inc., Sotio a.s., Morphogenesis, Inc., Checkpoint Therapeutics, Inc., and others.
• Promising Advanced Merkel Cell Carcinoma Pipeline Therapies includes XmAb18087, Pembrolizumab (MK-3475), FT500, Nivolumab, INCAGN02390, Etrumadenant, Zimberelimab, INCAGN02385, temsirolimus, vinorelbine ditartrate, INCAGN01949, Nivolumab, Ipilimumab, ABBV-181, and others.
• The Advanced Merkel cell carcinoma companies and academics are working to assess challenges and seek opportunities that could influence Advanced Merkel cell carcinoma R&D. The Advanced Merkel cell carcinoma pipeline therapies under development are focused on novel approaches to treat/improve Advanced Merkel cell carcinoma.
Advanced Merkel Cell Carcinoma Emerging Drugs Profile
• Tidutamab: Xencor, Inc.
Tidutamab (previously XmAb18087) is a bispecific antibody that engages the immune system against tumors by binding to somatostatin receptor 2 (SSTR2) and CD3. Xencor's XmAb® Bispecific Fc Domain serves as the scaffold for these two antigen binding domains and confers long circulating half-life, stability and ease of manufacture on tidutamab. Engagement of CD3 by tidutamab activates T cells for highly potent and targeted killing of SSTR2-expressing tumor cells.
• Cabozantinib: Exelixis
In the U.S., CABOMETYX tablets are approved for the treatment of patients with advanced renal cell carcinoma (RCC); for the treatment of patients with hepatocellular carcinoma (HCC) who have been previously treated with sorafenib; for patients with advanced RCC as a first-line treatment in combination with nivolumab; and for adult and pediatric patients 12 years of age and older with locally advanced or metastatic differentiated thyroid cancer (DTC) that has progressed following prior vascular endothelial growth factor receptor (VEGFR)-targeted therapy and who are radioactive iodine-refractory or ineligible. CABOMETYX tablets have also received regulatory approvals in the European Union and additional countries and regions worldwide. In 2016, Exelixis granted Ipsen Pharma SAS exclusive rights for the commercialization and further clinical development of cabozantinib outside of the U.S. and Japan.
Advanced Merkel Cell Carcinoma Pipeline Therapeutics Assessment
There are approx. 20+ key companies which are developing the therapies for Advanced Merkel cell carcinoma. The companies which have their Advanced Merkel cell carcinoma drug candidates in the most advanced stage, i.e. phase II include, Exelixis.
Get More Information on the Advanced Merkel cell carcinoma Drugs and Companies of Report @ Advanced Merkel cell carcinoma Ongoing Clinical Trials Analysis- https://www.delveinsight.com/sample-request/advanced-merkel-cell-carcinoma-pipeline-insight?utm_source=openpr&utm_medium=pressrelease&utm_campaign=ypr
Scope of the Advanced Merkel cell carcinoma Pipeline Report
• Coverage- Global
• Advanced Merkel Cell Carcinoma Companies- Xencor, Inc., Incyte Corporation, Millennium Pharmaceuticals, Inc., Exelixis, Bristol-Myers Squibb, bluebird bio, Affini-T Therapeutics, ImaginAb, Inc., BioInvent International AB, Ocellaris Pharma, Inc., Sotio a.s., Morphogenesis, Inc., Checkpoint Therapeutics, Inc., and others.
• Advanced Merkel Cell Carcinoma Pipeline Therapies- XmAb18087, Pembrolizumab (MK-3475), FT500, Nivolumab, INCAGN02390, Etrumadenant, Zimberelimab, INCAGN02385, temsirolimus, vinorelbine ditartrate, INCAGN01949, Nivolumab, Ipilimumab, ABBV-181, and others.
• Advanced Merkel Cell Carcinoma Pipeline Segmentation: Product Type, Molecule Type, Route of Administration
Find out more about the list of FDA-approved drugs for Advanced Merkel Cell Carcinoma @ Advanced Merkel Cell Carcinoma Treatment Landscape- https://www.delveinsight.com/sample-request/advanced-merkel-cell-carcinoma-pipeline-insight?utm_source=openpr&utm_medium=pressrelease&utm_campaign=ypr
Table of Content
1. Introduction
2. Executive Summary
3. Advanced Merkel cell carcinoma: Overview
4. Pipeline Therapeutics
5. Therapeutic Assessment
6. Advanced Merkel cell carcinoma - DelveInsight's Analytical Perspective
7. Mid Stage Products (Phase II)
8. Cabozantinib: Exelixis
9. Drug profiles in the detailed report…..
10. Early Stage Products (Phase I)
11. IFx-Hu2.0: Morphogenesis
12. Drug profiles in the detailed report…..
13. Inactive Products
14. Advanced Merkel cell carcinoma Key Companies
15. Advanced Merkel cell carcinoma Key Products
16. Advanced Merkel cell carcinoma- Unmet Needs
17. Advanced Merkel cell carcinoma- Market Drivers and Barriers
18. Advanced Merkel cell carcinoma- Future Perspectives and Conclusion
19. Advanced Merkel cell carcinoma Analyst Views
20. Advanced Merkel cell carcinoma Key Companies
21. Appendix
Got Queries? Find out the related information on Advanced Merkel Cell Carcinoma Preclinical and Discovery Stage Products @ Advanced Merkel Cell Carcinoma Drugs, Unmet Needs and Recent Trends- https://www.delveinsight.com/sample-request/advanced-merkel-cell-carcinoma-pipeline-insight?utm_source=openpr&utm_medium=pressrelease&utm_campaign=ypr
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DelveInsight is a Business Consulting and Market research company, providing expert business solutions for the healthcare domain and offering quintessential advisory services in the areas of R&D, Strategy Formulation, Operations, Competitive Intelligence, Competitive Landscaping, and Mergers & Acquisitions.
Company Name: DelveInsight Business Research LLP
Contact Person: Yash Bhardwaj
Email: ybhardwaj@delveinsight.com
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Country: United States
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