Linaclotide Market is estimated to grow at a CAGR of 7.15% within the forecast period of 2023-2030: Cognitive Market Research

Market Overview:
Linaclotide is a medication used to treat irritable bowel syndrome with constipation and chronic constipation with no known cause. It accelerates the passage of food through the gut by increasing the amount of fluid in the intestines. Linaclotide may improve the consistency of the stool and lessen symptoms such as abdominal pain/discomfort, straining, bloating, and feelings of incomplete bowel movements. Linaclotide works by selectively activating the guanylate cyclase-C (GC-C) receptor in the intestine. This activation increases the concentration of cyclic guanosine monophosphate (cGMP), which in turn leads to increases in the release of chloride and bicarbonate secretion into the intestinal lumen and decreased activity of pain-sensing neurons. These results help in enhancing bowel motions and reducing pain brought on by specific gastrointestinal disorders.
Linaclotide is primarily indicated for the treatment of two conditions:
a. irritable bowel syndrome with constipation (IBS-C): IBS-C is a common digestive illness characterized by changes in bowel movements, primarily constipation, as well as bloating and stomach pain or discomfort. Constipation and stomach pain are two symptoms of IBS-C that can be treated with linaclotide.
b. Chronic Idiopathic Constipation (CIC): CIC is the term used to describe constipation that does not cause by a structural or metabolic disorder. In CIC patients, linaclotide facilitates better bowel motions and reduces constipation.

Summary:
The Global Linaclotide market was valued at USD 1.29 Billion in 2022, registering a CAGR of 7.15% for the forecast period 2023-2030.

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Market Dynamics:
• Increasing prevalence of gastrointestinal disorders
The increasing prevalence of gastrointestinal disorders is a major driving factor contributing to the growth of the linaclotide market. Modern lifestyles involve sedentary behavior, unhealthy diets, and high levels of stress. These factors can disrupt digestive processes and contribute to the development of gastrointestinal disorders. Linaclotide has been available for the treatment of adults with irritable bowel syndrome with constipation (IBS-C) or chronic idiopathic constipation (CIC).
Gastrointestinal disorders are more common among older individuals. As the global aging population continues to rise, the prevalence of conditions such as irritable bowel syndrome (IBS), gastroesophageal reflux disease (GERD), and inflammatory bowel disease (IBD) is expected to increase in the coming years. For example, a large-scale multinational study reported that more than 40% of people worldwide suffer from gastrointestinal complications, such as diarrhea, constipation, or irritable bowel syndrome (IBS), with a prevalence of 4.7 %, 11.7%, and 4.1%, respectively.
In recent years, there has been a growing awareness and recognition of gastrointestinal disorders among both healthcare professionals and the general population. This has led to improved diagnostic techniques, earlier detection, and better reporting of these conditions, resulting in an apparent increase in prevalence. This has resulted in an increase in demand for linaclotide medications to treat such types of disorders. In addition, the consumption of processed foods, low-fiber diets, and high levels of refined sugars can lead to digestive problems. These dietary habits are increasingly prevalent, particularly in urban areas and developed countries, contributing to the increased prevalence of gastrointestinal disorders. All these factors contribute to the growth of the linaclotide market.

• Growing awareness about digestive health among people (Access Detailed Analysis in the Full Report Version)

• Rise in the aging population worldwide (Access Detailed Analysis in the Full Report Version)

Market Segmentation:
Treatment:
• Irritable bowel syndrome with constipation (IBS-C)
• Chronic idiopathic constipation (CIC)
Quality management is the major parameter to meet specific standards and specifications, reliability and consistency. The chemical and material industry is full of various types of chemicals and it is necessary to focus on quality management because it may affect environment & other equipment. Raw materials plays an important role in this industry. The chemical industry converts these raw materials into primary, secondary, and tertiary products. Fluctuations in raw material prices may impact the market growth in the near future. This study includes the revenue generation of each type in each region for the year 2018 to 2030. Additionally it also provides detailed supply chain analysis along with current trends in the market which are expected to propel the market growth in the coming year.

Application:
• Tablets
• Capsules

Dosage:
• 72 mcg
• 145 mcg
• 290 mcg

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Competitive Analysis for Linaclotide Market:
• Ironwood Pharmaceuticals Inc.
• Teva Pharmaceutical Industries Ltd.
• CordenPharma International
• Astellas Pharma Inc.
• Cayman Chemical Company
• SimSon Pharma Limited
• Others

Regional Analysis:
In 2022, North America has gained the largest market share. This is due to a well-established healthcare infrastructure, an increasing prevalence of gastrointestinal disorders, and growing awareness about digestive health among people. North America has a well-trained and skilled workforce of healthcare professionals, including doctors, nurses, researchers, and specialists. North American countries have made efforts to educate the public about digestive health and conditions like IBS. Furthermore, North America has a well-developed healthcare infrastructure, and individuals have relatively easier access to healthcare services, including gastrointestinal specialists. This facilitates timely diagnosis and treatment of IBS like Linactolide drugs. This will contribute to increasing the demand of the global market in the region.

Company Profile:
• Ironwood Pharmaceuticals, Inc
Ironwood Pharmaceuticals, Inc. is a gastrointestinal, or GI, healthcare company specializing in advancing the treatment of GI diseases and redefining the standard of care for GI patients. The company offers innovative products for several areas including irritable bowel syndrome with constipation, chronic idiopathic constipation, hyperuricemia associated with uncontrolled gout, uncontrolled gastroesophageal reflux disease, and vascular and fibrotic diseases.
Ironwood Pharmaceuticals, Inc. operates in one reportable business segment such as human therapeutics. Ironwood offers its products under two brands including Linzess and Constella. The company generates a pipeline of early development candidates and discovery research programs in various therapeutic areas which include gastrointestinal (GI), central nervous system (CNS), and allergic disorders.
The company's product portfolio comprises CNP-104, CNP-104, and IW-3300. It has strategic partnerships with leading pharmaceutical companies such as AbbVie Inc, for the development and commercialization of linaclotide across the globe.

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