Patient-Derived Xenograft/PDX Model Market size, demand, growth, COVID 19 Impact analyses, share, revenue and Forecast 2022-2032 | Charles River Laboratories , Crown Bioscience , WuXi AppTec

A patient-derived xenograft (PDX) is a cancer model created by transplanting tumor tissue from a human patient into an immunodeficient animal. This allows researchers to study the tumor in a living system and to test potential treatments.

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PDX models have several advantages over other types of cancer models. They more accurately reflect the heterogeneity of human tumors, and they can be used to study the interactions between the tumor and the host immune system. PDX models are also useful for studying the tumor microenvironment and for testing personalized treatments.

There are some challenges associated with PDX models, including the need for a large number of animals and the difficulty of creating models that accurately represent the diversity of human tumors.

Key Trends

There are a few key trends in Patient-Derived Xenograft/PDX Model technology. First, there is a trend towards using PDX models to study more rare diseases. This is because PDX models can provide a more accurate representation of the disease than cell lines or other models. Additionally, PDX models can be used to study the disease in its natural environment, which can provide insights that would not be possible with other model types.

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Another trend is the use of PDX models to study the efficacy of new treatments. This is because PDX models can be used to test the effectiveness of a treatment in a more realistic setting. Additionally, PDX models can be used to study the side effects of a treatment, which is important for safety purposes.

Additionally, there is a trend towards using PDX models to study disease progression. This is because PDX models can provide a more accurate representation of the disease than other model types. Additionally, PDX models can be used to study the disease in its natural environment, which can provide insights that would not be possible with other model types.

Key Drivers

The key drivers of the Patient-Derived Xenograft/PDX Model market are the increasing incidence of cancer, the availability of PDX models for a wide range of cancer types, and the increasing use of PDX models in drug development.

The incidence of cancer is increasing globally, with an estimated 18.1 million new cases and 9.6 million cancer-related deaths in 2018. The availability of PDX models for a wide range of cancer types is a key driver of the PDX market. PDX models are available for a variety of solid tumors, including breast, lung, colorectal, and pancreatic cancer, as well as for hematologic malignancies such as leukemia and lymphoma.

The use of PDX models in drug development is increasing, as they provide a more accurate representation of the human disease than cell line-derived xenografts (CDXs). PDX models are being used in a variety of drug development applications, including target validation, preclinical efficacy testing, and toxicity testing.

Restraints & Challenges

Patient-derived xenograft (PDX) models are increasingly being used in preclinical cancer research as they more accurately reflect the heterogeneity of human tumors than traditional cell line models. However, the development and use of PDX models is not without challenges.

One of the key challenges is the development of robust and reliable methods for the generation of PDX models. This is particularly challenging for solid tumors, which can be difficult to dissociate into single cells suitable for injection into immunodeficient mice.

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Another challenge is the characterization of PDX models. As PDX models are derived from patient tumors, they are heterogeneous in nature and can vary significantly in their molecular and phenotypic characteristics. This can make it difficult to compare results across different PDX models and to identify meaningful subgroups for study.

Key Market Segments

The patient-derived xenograft model market bifurcated on the basis of type, tumor type, end user, and region. On the basis of type it is segmented into mice models and rat models. By tumor type, it is divided into lung tumor models, respiratory tumor models, urological tumor models, and others. By end user, it is analyzed across academic and research organizations, contract research organizations, pharmaceutical and biotechnological companies, and others. Region-wise, it is studied across North America, Europe, Asia-Pacific, and rest of the World.

Key Market Players

The patient-derived xenograft model market report includes players such as Jackson Laboratory (USA). Charles River Laboratories (USA), Crown Bioscience (USA), WuXi AppTec (China), Champions Oncology (USA), Xenopat (Spain), Horizon Discovery (UK), EUROIMMUN AG (Germany), Oncodesign (France), and HuMurine Technologies (USA)

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