Relapsed/Refractory Acute Myeloid Leukemia Pipeline Outlook Report 2024

DelveInsight's, "Relapsed/refractory acute myeloid leukemia (AML) Pipeline Insight, 2024" report provides comprehensive insights about 50+ companies and 75+ pipeline drugs in Relapsed/refractory acute myeloid leukemia (AML) pipeline landscape. It covers the pipeline drug profiles, including clinical and nonclinical stage products. It also covers the therapeutics assessment by product type, stage, route of administration, and molecule type. It further highlights the inactive pipeline products in this space.

Key Takeaways from the Relapsed/Refractory Acute Myeloid Leukemia Pipeline Report
• DelveInsight's relapsed/refractory acute myeloid leukemia pipeline report depicts a robust space with 50+ active players working to develop 75+ pipeline therapies for relapsed/refractory acute myeloid leukemia treatment.
• The leading Relapsed/refractory acute myeloid leukemia companies such as Maxinovel Pty., Ltd., Cellectis S.A., Amgen, Ascentage Pharma, Shijiazhuang Yiling Pharmaceutical, CicloMed LLC, AB Science, Betta Pharmaceuticals Co., Ltd., Chongqing Precision Biotech Co., Ltd, Astellas Pharma, Keystone Nano, Cullinan Oncology, LLC, Arog Pharmaceuticals, Inc., GlycoMimetics Incorporated, Kite Pharma, Celyad Oncology SA, Novartis, PersonGen Biotherapeutics, Merck Sharp & Dohme LLC, Astex Pharmaceuticals, Mabwell (Shanghai) Bioscience Co., Ltd., Syndax Pharmaceuticals, Meryx, Inc., Cleave Therapeutics, Aptose Biosciences Inc., New Epsilon Innovation Limited, Guangdong Ruishun Biotech Co., Ltd, Hoffmann-La Roche, Prelude Therapeutics, Lava Therapeutics, Precigen, Inc, Celularity Incorporated, CSPC ZhongQi Pharmaceutical Technology Co., Ltd., JW Pharmaceutical, Eisai Inc., Wugen, Inc., Sumitomo Pharma Oncology, Inc., ADC Therapeutics S.A., ImmunoGen, Inc., Aptevo Therapeutics, Foghorn Therapeutics, TC Biopharm, Nanjing Sanhome Pharmaceutical, Co., Ltd., Nkarta Inc., Newave Pharmaceutical Inc, and others are evaluating new drugs for relapsed/refractory acute myeloid leukemia to improve the treatment landscape.
• Promising Relapsed/refractory acute myeloid leukemia pipeline therapies in various stages of development include MAX-40279-01, UCART123v1.2, AMG 427, AMG 553, APG-2575, XY0206, Fosciclopirox, AB8939, MRX2843, CD123 CAR-T cells, ASP7517, Ceraxa, CLN-049, Crenolanib, Uproleselan, KITE-222, CYAD-02, VOB560, TAA05, MK-0482, ASTX660, 6MW3211, SNDX-5613, MRX-2843, CB-5339, CG-806, NEI-01, RC1012, RO7283420, IO-202, PRT1419, LAVA-051, PRGN-3006 T Cells, CYNK-001, SKLB1028, CWP232291, E7820, WU-NK-101, DSP-533, ADCT-301,I MGN632, APVO436, FHD-286, TCB008, SH1573, NKX101 - CAR NK cell therapy, LP-108, and others.
• The Relapsed/Refractory Acute Myeloid Leukemia Companies and academics are working to assess challenges and seek opportunities that could influence Relapsed/refractory acute myeloid leukemia (AML) R&D. The Relapsed/Refractory Acute Myeloid Leukemia pipeline therapies under development are focused on novel approaches to treat/improve Relapsed/refractory acute myeloid leukemia (AML).
• April 2024: Astellas Pharma Korea Inc- An Observational Study to Assess the Safety of Xospata® 40 mg Tablet When Administered in Patients With Relapsed or Refractory Acute Myeloid Leukemia (AML) With FMS-Like Tyrosine Kinase 3 (FLT3) Mutation.
• April 2024: AbbVie announced a study of Phase 1 clinical trials for ABBV-787. Acute myeloid leukemia (AML) is the second most common type of leukemia diagnosed in adults and children, but most cases occur in adults. This study is to evaluate how safe ABBV-787 is and how it moves within the body in adult participants with relapsed/refractory (R/R) acute myeloid leukemia (AML). Adverse events and maximum tolerated dose (MTD) of ABBV-787 will be assessed.

To explore more information on the latest breakthroughs in the Relapsed/Refractory Acute Myeloid Leukemia Pipeline treatment landscape of the report, click here @ Relapsed/Refractory Acute Myeloid Leukemia Pipeline Outlook- https://www.delveinsight.com/report-store/relapsed-refractory-acute-myeloid-leukemia-r-r-aml-pipeline-insight?utm_source=openpr&utm_medium=pressrelease&utm_campaign=ypr

Relapsed/Refractory Acute Myeloid Leukemia Overview
Relapsed/refractory acute myeloid leukemia (AML) is a devastating disease with a poor prognosis and represents a major unmet medical need. The prognosis of relapsed acute myeloid leukemia (AML) is poor and treatment is challenging. The signs and symptoms of acute myeloid leukemia (AML) are common to other, less serious illnesses. It is common for people with AML to feel a loss of well-being because of the underproduction of normal bone marrow cells. Symptoms of a low red blood cell count (called "anemia") include: Fatigue, weakness, shortness of breath during normal physical activities, lightheadedness, dizziness or faintness, headaches and pale complexion. Other general symptoms of AML include: Loss of appetite, unexplained weight loss, discomfort in bones or joints, fullness or swelling in the abdomen, due to an enlarged spleen or liver.

Request a sample and discover the recent advances in Relapsed/Refractory Acute Myeloid Leukemia Ongoing Clinical Trial Analysis and Medications, click here @ Relapsed/Refractory Acute Myeloid Leukemia Treatment Landscape- https://www.delveinsight.com/sample-request/relapsed-refractory-acute-myeloid-leukemia-r-r-aml-pipeline-insight?utm_source=openpr&utm_medium=pressrelease&utm_campaign=ypr

Relapsed/refractory acute myeloid leukemia (AML) Emerging Drugs Profile

APG-2575: Ascentage Pharma
APG-2575 is a novel oral Bcl-2 selective small molecule inhibitor under development by Ascentage Pharma. It restores the programmed cell death mechanism (apoptosis) of tumor cells by selectively inhibiting Bcl-2 protein, thereby inducing tumor cell apoptosis. , to achieve the purpose of tumor treatment. APG-2575 is the first locally developed Bcl-2 selective inhibitor to enter clinical stage in China. APG-2575 has been granted orphan drug designation by the US FDA for five indications (Indications: refractory chronic lymphocytic leukemia CLL, multiple myeloma, Waldenström macroglobulinemia, acute myeloid leukemia, follicular lymphoma).

CLN 049: Cullinan Oncology
CLN-049 (Florentine) is a humanized bispecific T cell engaging antibody being developed for the treatment of acute myeloid leukemia (AML). CLN-049 is designed to simultaneously bind to FLT3 on targeted leukemic cells and to CD3 on T cells, triggering the T cells to kill the selected cancer cells via their intrinsic cytolytic mechanisms. FLT3 is expressed frequently on AML cells and leukemic blasts but minimally on healthy blood cells, unlike other tumor surface antigens identified in AML, such as CD33 and CD123. CLN-049 can mediate potent and specific lysis of AML cells in vitro and promotes enhanced survival of mice bearing AML tumors. A phase I clinical trial with CLN-049 is currently ongoing for the treatment of patients with relapsed/refractory AML or MDS.

Lanraplenib: Kronos Bio
Lanraplenib, is a next-generation SYK inhibitor that has previously been studied as a potential treatment for autoimmune diseases. In preclinical studies, Lanraplenib was shown to have anti-leukemic activity against NPM1-mutated and FLT3-mutated AML samples. Lanraplenib, is being developed for the treatment of patients with relapsed/refractory FLT3-mutated AML and patients newly diagnosed with NPM1-mutated and/orFLT3-mutated AML who are older than 75 years old or are not eligible for intensive induction chemotherapy.

Relapsed/Refractory Acute Myeloid Leukemia Pipeline Therapeutics Assessment
There are approx. 50+ key companies which are developing the therapies for Relapsed/refractory acute myeloid leukemia (AML). The companies which have their Relapsed/refractory acute myeloid leukemia (AML) drug candidates in the most advanced stage, i.e. Phase I/II include, Ascentage Pharma.

DelveInsight's report covers around 75+ products under different phases of clinical development like
• Late stage products (Phase III)
• Mid-stage products (Phase II)
• Early-stage product (Phase I) along with the details of
• Pre-clinical and Discovery stage candidates
• Discontinued & Inactive candidates

Relapsed/refractory acute myeloid leukemia (AML) pipeline report provides the therapeutic assessment of the pipeline drugs by the Route of Administration. Products have been categorized under various ROAs such as
• Intra-articular
• Intraocular
• Intrathecal
• Intravenous
• Ophthalmic
• Oral
• Parenteral
• Subcutaneous
• Topical
• Transdermal

Molecule Type
Products have been categorized under various Molecule types such as
• Oligonucleotide
• Peptide
• Small molecule

For further information, refer to the detailed Relapsed/Refractory Acute Myeloid Leukemia Unmet Needs, Relapsed/Refractory Acute Myeloid Leukemia Market Drivers, and Market Barriers, click here for Relapsed/Refractory Acute Myeloid Leukemia Ongoing Clinical Trial Analysis- https://www.delveinsight.com/sample-request/relapsed-refractory-acute-myeloid-leukemia-r-r-aml-pipeline-insight?utm_source=openpr&utm_medium=pressrelease&utm_campaign=ypr

Scope of the Relapsed/Refractory Acute Myeloid Leukemia Pipeline Report
• Coverage- Global
• Companies- as Maxinovel Pty., Ltd., Cellectis S.A., Amgen, Ascentage Pharma, Shijiazhuang Yiling Pharmaceutical, CicloMed LLC, AB Science, Betta Pharmaceuticals Co., Ltd., Chongqing Precision Biotech Co., Ltd, Astellas Pharma, Keystone Nano, Cullinan Oncology, LLC, Arog Pharmaceuticals, Inc., GlycoMimetics Incorporated, Kite Pharma, Celyad Oncology SA, Novartis, PersonGen Biotherapeutics, Merck Sharp & Dohme LLC, Astex Pharmaceuticals, Mabwell (Shanghai) Bioscience Co., Ltd., Syndax Pharmaceuticals, Meryx, Inc., Cleave Therapeutics, Aptose Biosciences Inc., New Epsilon Innovation Limited, Guangdong Ruishun Biotech Co., Ltd, Hoffmann-La Roche, Prelude Therapeutics, Lava Therapeutics, Precigen, Inc, Celularity Incorporated, CSPC ZhongQi Pharmaceutical Technology Co., Ltd., JW Pharmaceutical, Eisai Inc., Wugen, Inc., Sumitomo Pharma Oncology, Inc., ADC Therapeutics S.A., ImmunoGen, Inc., Aptevo Therapeutics, Foghorn Therapeutics, TC Biopharm, Nanjing Sanhome Pharmaceutical, Co., Ltd., Nkarta Inc., Newave Pharmaceutical Inc, and others.
• Pipeline Therapies- MAX-40279-01, UCART123v1.2, AMG 427, AMG 553, APG-2575, XY0206, Fosciclopirox, AB8939, MRX2843, CD123 CAR-T cells, ASP7517, Ceraxa, CLN-049, Crenolanib, Uproleselan, KITE-222, CYAD-02, VOB560, TAA05, MK-0482, ASTX660, 6MW3211, SNDX-5613, MRX-2843, CB-5339, CG-806, NEI-01, RC1012, RO7283420, IO-202, PRT1419, LAVA-051, PRGN-3006 T Cells, CYNK-001, SKLB1028, CWP232291, E7820, WU-NK-101, DSP-533, ADCT-301,I MGN632, APVO436, FHD-286, TCB008, SH1573, NKX101 - CAR NK cell therapy, LP-108, and others.
• Relapsed/refractory acute myeloid leukemia Pipeline Segmentation: Product Type, Molecule Type, Route of administration, Mechanism of action

Dive deep into rich insights for drugs for Relapsed/Refractory Acute Myeloid Leukemia Market Drivers and Relapsed/Refractory Acute Myeloid Leukemia Market Barriers, click here @ Relapsed/Refractory Acute Myeloid Leukemia Unmet Needs and Analyst Views- https://www.delveinsight.com/sample-request/relapsed-refractory-acute-myeloid-leukemia-r-r-aml-pipeline-insight?utm_source=openpr&utm_medium=pressrelease&utm_campaign=ypr

Table of Content
1. Introduction
2. Executive Summary
3. Relapsed/refractory acute myeloid leukemia (AML): Overview
4. Pipeline Therapeutics
5. Therapeutic Assessment
6. Relapsed/refractory acute myeloid leukemia (AML)- DelveInsight's Analytical Perspective
7. Late Stage Products (Phase III)
8. Drug name : Company name
9. Drug profiles in the detailed report…..
10. Mid Stage Products (Phase I/II)
11. APG-2575: Ascentage Pharma
12. Drug profiles in the detailed report…..
13. Early Stage Products (Phase I)
14. CLN 049: Cullinan Oncology
15. Drug profiles in the detailed report…..
16. Preclinical and Discovery Stage Products
17. Drug name : Company name
18. Drug profiles in the detailed report…..
19. Inactive Products
20. Relapsed/refractory acute myeloid leukemia (AML) Key Companies
21. Relapsed/refractory acute myeloid leukemia (AML) Key Products
22. Relapsed/refractory acute myeloid leukemia (AML)- Unmet Needs
23. Relapsed/refractory acute myeloid leukemia (AML)- Market Drivers and Barriers
24. Relapsed/refractory acute myeloid leukemia (AML)- Future Perspectives and Conclusion
25. Relapsed/refractory acute myeloid leukemia (AML) Analyst Views
26. Relapsed/refractory acute myeloid leukemia (AML) Key Companies
27. Appendix

Got Queries? Find out the related information on Relapsed/refractory acute myeloid leukemia Mergers and acquisitions, Relapsed/refractory acute myeloid leukemia licensing activities @ Relapsed/refractory acute myeloid leukemia Emerging Drugs, and Recent Trends- https://www.delveinsight.com/sample-request/relapsed-refractory-acute-myeloid-leukemia-r-r-aml-pipeline-insight?utm_source=openpr&utm_medium=pressrelease&utm_campaign=ypr

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