Leiomyosarcoma Pipeline 2024 | Merck, Advenchen Laboratories, Trillium Therapeutics, PTC Therapeutics, PharmaMar, Philogen, EMD Serono, Incyte Corporation, Clovis Oncology Inc.

DelveInsight's, "Leiomyosarcoma Pipeline Insight 2024" report provides comprehensive insights about 10+ companies and 10+ pipeline drugs in Leiomyosarcoma pipeline landscape. It covers the pipeline drug profiles, including clinical and nonclinical stage products. It also covers the therapeutics assessment by product type, stage, route of administration, and molecule type. It further highlights the inactive pipeline products in this space.

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Key Takeaways from the Leiomyosarcoma Pipeline Report

* June 2024:- PharmaMar- Randomized, Controlled, Open-label, Phase IIb/III Study of Lurbinectedin in Combination With Doxorubicin Versus Doxorubicin Alone as First-line Treatment in Patients With Metastatic Leiomyosarcoma. The primary objective of this phase IIb/III study is to evaluate whether the combination of lurbinectedin plus doxorubicin given as first line treatment for metastatic leiomyosarcoma (LMS) prolongs the progression-free survival (PFS) by Independent Review Committee (IRC) when compared to doxorubicin administered as a single agent.
* June 2024:- PTC Therapeutics - A Phase 2/3 Study to Evaluate the Efficacy and Safety of Unesbulin in Unresectable or Metastatic, Relapsed or Refractory Leiomyosarcoma. This study will compare the efficacy and safety of unesbulin plus dacarbazine versus placebo plus dacarbazine in participants with unresectable or metastatic, relapsed or refractory LMS who have received at least 1 prior line of systemic therapy.
* DelveInsight's Leiomyosarcoma Pipeline analysis depicts a robust space with 10+ active players working to develop 10+ pipeline treatment therapies.
* The leading Leiomyosarcoma Companies such as Merck, Advenchen Laboratories, Trillium Therapeutics, PTC Therapeutics, PharmaMar, Philogen, EMD Serono, Incyte Corporation, Clovis Oncology, Inc., and others.
* Promising Leiomyosarcoma Therapies such as Lurbinectedin, Doxorubicin, Unesbulin, Dacarbazine, Rucaparib, Nivolumab, Dinutuximab Beta, Zoledronic acid, Interleukin-2, and others.

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Leiomyosarcoma Emerging Drugs Profile

* ADI PEG20: Polaris Group

ADI-PEG 20 is a first-in-class therapeutic approach to deplete arginine and starve cancer cells. Because arginine is one of the 20 amino acids that are essential for protein synthesis and survival of cells, some cancer cells become dependent upon the external supply of arginine to survive and grow. ADI-PEG 20 is designed to deplete the external supply of arginine, which causes arginine-dependent cancer cells to die while leaving the patient's normal cells unharmed. Currently, it is in Phase III stage of clinical trial evaluation to treat Leiomyosarcoma.

* OR2805: OncoResponse

OR2805 is a fully human monoclonal antibody that targets CD163, an immune-suppressive receptor highly expressed on tumor-associated macrophages (TAMs). It was discovered using B cells derived from an elite responder to checkpoint inhibitor (CPI) therapy and is designed to reverse the immunosuppressive effect of TAMs, enhancing anti-tumor T-cell responses. In preclinical studies, OR2805 showed significant anti-tumor activity in lung cancer xenograft models in humanized mice and relieved the suppressive effect of M2c macrophages in coculture assays. OR2805 is currently being evaluated in a Phase I/II clinical trial to assess its safety, pharmacokinetics, pharmacodynamics, and preliminary anti-tumor activity in patients with Leiomyosarcoma. The trial includes a dose-escalation phase, expansion cohorts, and a biology cohort to evaluate potential biomarkers. OR2805 has the potential to improve anti-tumor T-cell responses by reversing the immunosuppressive effect of TAMs, making it a promising therapeutic strategy for treating advanced cancers.

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Leiomyosarcoma Companies

Merck, Advenchen Laboratories, Trillium Therapeutics, PTC Therapeutics, PharmaMar, Philogen, EMD Serono, Incyte Corporation, Clovis Oncology, Inc., and others.

Leiomyosarcoma pipeline report provides the therapeutic assessment of the pipeline drugs by the Route of Administration

* Oral
* Parenteral
* Intravenous
* Subcutaneous
* Topical.

Leiomyosarcoma Products have been categorized under various Molecule types such as

* Monoclonal Antibody
* Peptides
* Polymer
* Small molecule
* Gene therapy

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Scope of the Leiomyosarcoma Pipeline Report

* Coverage- Global
* Leiomyosarcoma Companies- Merck, Advenchen Laboratories, Trillium Therapeutics, PTC Therapeutics, PharmaMar, Philogen, EMD Serono, Incyte Corporation, Clovis Oncology, Inc., and others.
* Leiomyosarcoma Therapies- Lurbinectedin, Doxorubicin, Unesbulin, Dacarbazine, Rucaparib, Nivolumab, Dinutuximab Beta, Zoledronic acid, Interleukin-2, and others.
* Leiomyosarcoma Therapeutic Assessment by Product Type: Mono, Combination, Mono/Combination
* LeiomyosarcomaTherapeutic Assessment by Clinical Stages: Discovery, Pre-clinical, Phase I, Phase II, Phase III

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Table of Content

* Introduction
* Executive Summary
* Leiomyosarcoma: Overview
* Pipeline Therapeutics
* Therapeutic Assessment
* Leiomyosarcoma - DelveInsight's Analytical Perspective
* In-depth Commercial Assessment
* Leiomyosarcoma Collaboration Deals
* Late Stage Products (Phase III)
* AL-3818: Advenchen Laboratories
* Drug profiles in the detailed report.....
* Mid Stage Products (Phase II)
* Drug Name: Company Name
* Drug profiles in the detailed report.....
* Early Stage Products (Phase I)
* OR2805: OncoResponse
* Drug profiles in the detailed report.....
* Inactive Products
* Leiomyosarcoma Key Companies
* Leiomyosarcoma Key Products
* Leiomyosarcoma- Unmet Needs
* Leiomyosarcoma- Market Drivers and Barriers
* Leiomyosarcoma- Future Perspectives and Conclusion
* Leiomyosarcoma Analyst Views
* Leiomyosarcoma Key Companies
* Appendix

About Us

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