Press release
NGS Sample Preparation Market Poised for Explosive Growth, Set to Triple by 2035 Key Players Macrogen, Inc., Eurofins Scientific, Illumina, Inc., F Hoffman-La Roche AG and Others
A new market analysis projects the global Next-Generation Sequencing (NGS) Sample Preparation market to experience a significant surge, forecasting a valuation of USD 7.0 billion by 2035. This marks a substantial increase from its estimated USD 1.9 billion value in 2025, reflecting a robust Compound Annual Growth Rate (CAGR) of 13.7% over the decade. The findings underscore the pivotal role of sample preparation in the expanding field of genomics, driven by advancements in personalized medicine, clinical diagnostics, and research.The report highlights that the demand for sophisticated, high-throughput sample preparation solutions is accelerating as sequencing technologies become more affordable and widespread. Key drivers fueling this growth include a greater focus on rare disease diagnostics, increasing government funding for large-scale genomic projects, and the need for streamlined, automated workflows to ensure data quality and reproducibility.
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Market Segments and Key Trends
In 2025, the market's leading technology segment is Sequencing by Synthesis (SBS), which is projected to capture a 43.0% revenue share. This dominance is attributed to SBS's high accuracy, scalability, and broad compatibility with diverse genomic applications. Its strong market position is further solidified by continuous technological refinements and manufacturer support from key players like Illumina.
The Diagnostics application segment is another major growth area, anticipated to hold a 34.0% share of the market in 2025. This expansion is a direct result of the growing integration of NGS into clinical settings for early and accurate detection of diseases, particularly in oncology and infectious disease surveillance. The rising demand for companion diagnostics and pharmacogenomics is propelling the need for reliable and automated sample preparation platforms that can meet stringent clinical standards.
Research Institutes are identified as the leading end-use segment, expected to account for 36.0% of the market revenue in 2025. This is driven by their central role in academic and government-funded research, where large-scale sequencing projects require robust and flexible preparation systems. These institutions also serve as critical validation sites for new protocols, influencing wider commercial adoption.
Regional Market Landscape
Geographically, North America is predicted to maintain its lead in the NGS sample preparation market, with an estimated 37.6% market share in 2025. This is largely due to a well-established biopharmaceutical industry, advanced healthcare infrastructure, and favorable public and private initiatives supporting genomic research. Following North America, Europe is set to hold a 23.8% market share, driven by a strong research focus and the needs of an aging population. The Asia-Pacific region is also emerging as a key growth hub, fueled by rising investments in healthcare and genomics.
Competitive Landscape and Innovation
The NGS sample preparation market is home to several key players, including Thermo Fisher Scientific, Agilent Technologies, Inc., F Hoffman-La Roche AG, Illumina, Inc., Eurofins Scientific, and Macrogen, Inc. These companies are actively diversifying their revenue streams by exploring new opportunities in agriculture and animal research, in addition to traditional medical services. For instance, some are developing new NGS protocols for veterinary virology to address the lack of species-specific solutions.
The market also features a vibrant startup ecosystem. A notable example is SimplSeq, a spinout from Murrieta Genomics, which is beta-testing a novel, simpler, and faster technology that claims to eliminate the need for DNA/RNA purification. Such innovations are poised to challenge established players by making sample preparation more efficient and accessible, particularly for liquid biopsy and other precious sample materials.
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Market Comparison and Outlook
When compared to the broader Next-Generation Sequencing (NGS) market, the sample preparation segment's growth rate is a crucial indicator of the industry's maturation. While the overall NGS market is also expanding, the significant investment and innovation in the sample preparation segment-the vital first step of any sequencing workflow-shows a growing recognition of its importance for achieving high-quality, reliable, and standardized results. The shift toward automated, error-free protocols is a clear response to the increasing complexity and scale of genomic projects.
Despite the rapid growth, challenges remain. The high capital cost of automated systems and regulatory hurdles, such as delays in obtaining FDA approval for molecular diagnostics, can impact market expansion. However, continued technological advancements, strategic collaborations, and a strong push toward personalized medicine and diagnostics are expected to overcome these obstacles, propelling the NGS sample preparation market toward its ambitious 2035 forecast.
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Complete PDF Guide to NGS Sample Preparation
The NGS sample preparations determine components in the samples, such as blood, urine, and others, in animals.
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The type of analyzers includes urine analyzers, blood gas & electrolyte analyzers, glucometers, and others used by medical labs, hospitals, and people at home.
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