Key Factor Supporting Global Long-Read Sequencing Market Development in 2025: Increasing Prevalence Of Genetic Diseases Fueling The Growth Of The Market Due To Rising Demand For Accurate Diagnosis And Personalized Treatment

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How Large Will the Long-Read Sequencing Market Size By 2025?
The market for long-read sequencing has seen a substantial increase in size over the recent years. The projections indicate an increase from $0.91 billion in 2024 to $1.15 billion in 2025, reflecting a compound annual growth rate (CAGR) of 26.9%. Factors that contributed to this growth in the past period include the growing need for high-throughput genomic analysis, the widespread use in academic research, its increasing popularity for structural variant detection, the surge in government-funded genome projects, and rising usage in plant and animal genomics.

How Big Is the Long-Read Sequencing Market Size Expected to Grow by 2029?
In the upcoming years, the market size for long-read sequencing is predicted to undergo remarkable growth. It is projected to reach $2.96 billion in 2029, with a compound annual growth rate (CAGR) of 26.6%. This growth during the forecast period can be linked to factors such as the escalating use in precision medicine, the surge in investments for genomic infrastructure, the expanding use in clinical diagnostics, an increase in studies using long-read sequencing for rare diseases, and a growing demand for extensive epigenetic profiling. The forecast period will also witness major trends such as progress in sequencing chemistry, the incorporation of AI-based data analytics, innovation in compact sequencing devices, the creation of cost-effective consumables, and developments in multi-omics workflow solutions.

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Which Key Market Drivers Powering Long-Read Sequencing Market Expansion and Growth?
The growth of the long-read sequencing market is expected to accelerate due to the rising incidence of genetic diseases. Genetic diseases stem from alterations or defects in DNA and can be either inherited or emerge spontaneously. These diseases impact individuals' health, growth, or bodily functions. This surge in the number of genetic diseases can be attributed to growing awareness and technological advancements in diagnostics which lead to the early and precise identification of previously non-diagnosed conditions. The management of genetic diseases is significantly improved by long-read sequencing due to its ability to provide comprehensive and highly accurate genomic information. Hence, it's ideal for the diagnosis of complex and rare conditions. It eliminates diagnostic uncertainty by detecting structural variations and complex mutations, thereby enhancing personalized treatment and clinical decision-making. For example, the Cystic Fibrosis Trust, a UK-based national charity, revealed in September 2023 that there was a rise in the number of patients diagnosed with cystic fibrosis (CF) in 2022, reaching 11,148 from 10,908 in 2021. As a result, the growing rates of genetic diseases are fueling the expansion of the long-read sequencing market.

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Which Fast-Growing Trends Are Poised to Disrupt the Long-Read Sequencing Market?
Key participants in the long-read sequencing market are prioritizing the development of novel solutions like HiFi reads. This initiative is designed to improve sequencing accuracy, identify sophisticated genetic variations, and hasten genomic research. High-Fidelity (HiFi) reads denote long DNA sequences produced by specific long-read sequencing technologies. The technique offers both prolonged reading lengths and incredibly low error rates, hence, facilitating the precise identification of intricate genetic variants and structural alterations. For example, Pacific Biosciences of California Inc., a biotech firm located in the USA, introduced a Vega system in November 2024. This is the company's premiere benchtop long-read sequencing platform intended for quick, readily accessible genomic analysis. The reasonably priced compact Vega is a benchtop long-read sequencer that yields highly accurate HiFi data with a read accuracy of 99.9%. It paves the way for rapid, flexible sequencing for applications like RNA, targeted, and small genome sequencing, thus extending advanced genomics capacity to additional labs. Vega streamlines workflows with inbuilt computing and straightforward operation, thus enabling researchers to efficiently extract complex genetic insights.

What Are the Emerging Segments in the Long-Read Sequencing Market?
The long-read sequencing market covered in this report is segmented as

1) By Product And Service: Instruments Or Platforms, Consumables And Reagents, Services And Software
2) By Workflow: Pre-Sequencing, Sequencing, Data Analysis
3) By Technology Platform: Single Molecule Real-Time (SMRT) High-Fidelity (HiFi) Sequencing, Synthetic Long-Read Or Linked-Read, Hybrid And Other Emerging
4) By Application: Human Genomics And Rare-Disease Diagnostics, Oncology And Liquid Biopsy, Metagenomics And Microbiome, Transcriptomics, Agri Genomics And Plant Or Animal Breeding, Other Applications
5) By End User: Academic And Research Institutes, Hospitals And Clinics, Pharmaceutical And Biotechnology Companies, Other End-Uses

Subsegments:
1) By Instruments Or Platforms: Single-Molecule Real-Time (SMRT) Sequencers, Nanopore Sequencers
2) By Consumables And Reagents: Library Preparation Kits, Sample Preparation Kits, Sequencing Kits
3) By Services And Software: Sequencing Services, Data Analysis Services, Bioinformatics Software

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Who Are the Global Leaders in the Long-Read Sequencing Market?
Major companies operating in the long-read sequencing market are Thermo Fisher Scientific Inc., Agilent Technologies Inc., Illumina Inc., Revvity Inc., Bio-Rad Laboratories Inc., BGI Genomics Co. Ltd., Novogene Co. Ltd., Takara Bio Inc., Oxford Nanopore Technologies plc, Pacific Biosciences of California Inc., New England Biolabs Inc., Roche Sequencing Solutions Inc., The Garvan Institute, MGI Tech Co. Ltd., Element Biosciences Inc., Eurofins Genomics, CD Genomics, BaseClear B.V, France Génomique, GrandOmics Biosciences Co. Ltd., Future Genomics Technologies B.V., and MicrobesNG

Which are the Top Profitable Regional Markets for the Long-Read Sequencing Industry?
North America was the largest region in the long-read sequencing market in 2024. Asia-Pacific is expected to be the fastest-growing region in the forecast period. The regions covered in long-read sequencing report are Asia-Pacific, Western Europe, Eastern Europe, North America, South America, Middle East and Africa.

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