Tumor Necrosis Factor Inhibitors Market & TNF Inhibitors Clinical Pipeline Outlook 2022

The search for the effective therapeutic approaches in the modulation of the TNF has been focus of the research efforts. Approximately 1 Million people in the worldwide either undergoing the treatment or have been treated with the TNF inhibitors which are available in the pharmaceutical market which surrounding the indications that include the rheumatoid arthritis, psoriatic arthritis, psoriasis and inflammatory bowel diseases.

The neutralization of the TNF signaling can be achieved at the different levels, level of the ligand, level of the receptors and of the intracellular signal pathways. The approved anti-TNF therapies all interfere at the level of the ligand by directly binding to TNF and thus by preventing its interaction with both the TNF receptors. The five structurally different anti-TNF drugs are approved for the treatment of the various inflammatory diseases.

The drugs which are commonly used as immunosuppressant for example cyclosporine A and dexamethasone which display the TNF-α modulation, although their effects are related with considerable toxicity. However, as the mechanisms that comprise the production of TNF and its activity on cells, it become well understood, more specific strategies for the inhibition of the cytokine emerge. Examples contain the development of new therapeutic agents and the alteration of the existing ones, seeking the lower toxicity, greater potency and a larger number of clinical substitutions.

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Report Table of Contents

Introduction to Tumor Necrosis Factor (TNF)
1.1 Basic Structure of the Tumor Necrosis Factor (TNF) Molecule
1.2 Significance of Tumor Necrosis Factor for the Biosynthesis Regulation
1.2.1 Regulation of TNF Biosynthesis at the Transcriptional Level
1.2.2 Regulation the TNF at the Receptor Level
1.3 Tumor Necrosis Factor Receptors

Tumor Necrosis Factor Receptor Signaling Pathway
2.1 Tumor Necrosis Factor Receptor1 (TNFR1) Signaling
2.2 Tumor Necrosis Factor Receptor 2 (TNFR 2) Signaling

Overview of Tumor Necrosis Factor Inhibitors
3.1 Mechanism of Action of Tumor Necrosis Factor Inhibitors
3.2 Mechanism of Action of Remicade in the Inflammatory Diseases
3.3 Mechanism of Action of the Etanercept
3.4 Mechanism of Action of Humira

Approaches Used in Development of Anti-TNF
4.1 Monoclonal Antibody Approach
4.2 Recombinant DNA Technology Approach

Function of TNF in Immune Mediated Inflammatory Diseases
5.1 Rheumatoid Arthritis
5.2 Crohn's Disease
5.3 Psoriasis and Psoriatic Arthritis

Involvement of TNF and its Receptor in Neurodegenerative Disorders
6.1 Alzheimer’s Diseases
6.2 Parkinson’s Diseases
6.3 Ischemic Stroke
6.4 Multiple Sclerosis

Role of the Tumor Necrosis Factor in the Development of the Cancer
7.1 Introduction
7.2 Tumor Necrosis Factor as Carcinogen
7.3 Tumor Necrosis Factor as an Anti-Cancer Agent

TNF Inhibitors Market Overview
8.1 Market of Anti-TNF Blockbuster Drugs
8.1.1 Market of Humira
8.1.2 Market of Enbrel
8.1.3 Market of Remicade
8.2 Global Tumor Necrosis Factor Inhibitors Pipeline Overview

Global TNF Inhibitors Market Dynamics
9.1 Accelerative Parameters to the TNF Inhibitor Market
9.2 Challenges to the TNF Inhibitor Market

Future Implications of TNF Inhibitor Market

Global Tumor Necrosis Factor Inhibitors Pipeline by Company, Indication and Phase
11.1 Unknown
11.2 Research
11.3 Preclinical
11.4 Clinical
11.5 Phase-I
11.6 Phase-I/II
11.7 Phase-II
11.8 Phase-II/III
11.9 Phase-III
11.10 Preregistration
11.11 Registered

Marketed Tumor Necrosis Factor Inhibitors Clinical Insight
12.1 Lumbricus Rubellus Extract (Disolf)
12.2 Certolizumab Pegol (Cimzia, Simziya)
12.3 Apremilast (Otezla)
12.4 Lenalidomide (Ladevina, Revlimid)
12.5 Adalimumab (Humira, Raheara)
12.6 Etanercept (Enbrel)
12.7 Infliximab Biosimilar (Inflectra, Remsima)
12.8 Adalimumab Biosimilar
12.9 Pomalidomide (Imnovid, Pomalyst)
12.10 Belimumab (Benlysta)
12.11 Etanercept Biosimilar (Infinitam)
12.12 Golimumab (Simponi)
12.13 Infliximab Biosimilar (Infimab)
12.14 Infliximab (Remicade)
12.15 Etanercept Biosimilar (Intacept)
12.16 Iguratimod (Careram, Kolbet)
12.17 Thalidomide (Thaled, Thalidomide Celgene, Thalomid)
12.18 Infliximab Biosimilar
12.19 Adalimumab Biosimilar (Exemptia)
12.20 Etanercept Biosimilar (Iran)
12.21 Etanercept Biosimilar (Etacept, Etanar, Yisaipu)
12.22 Iguratimod
12.23 Anti-Tumour Necrosis Factor-Alpha Antibody Oral
12.24 Pentoxifylline (Claudicat, Dospan Pento, Elorgan, Pentoxifilina, Trental)
12.25 Sho-seiryu-to

TNF Inhibitors Suspended in Clinical Pipeline
13.1 No Development Reported
13.2 Discontinued
13.3 Suspended

Competitive Landscape
14.1 AbbVie
14.2 Ablynx
14.3 Apogenix
14.4 AryoGen Biopharma
14.5 Bionovis
14.6 CASI Pharmaceuticals
14.7 Celltrion
14.8 Celgene Corporation
14.9 Delenex Therapeutics
14.10 Dexa Medica
14.11 EPIRUS Biopharmaceuticals
14.12 Janssen Biotech
14.13 GlaxoSmithKline
14.14 HanAll Biopharma
14.15 Intas Pharmaceuticals
14.16 LEO Pharma
14.17 LG Life Sciences
14.18 MedImmune
14.19 Momenta Pharmaceuticals
14.20 Novartis
14.21 PROBIOMED
14.22 Reliance Life Sciences
14.23 Sandoz
14.24 Samsung Bioepis
14.25 Sanofi-Aventis
14.26 Shanghai CP Guojian Pharmaceutical
14.27 Shanghai Pharmaceuticals
14.28 Simcere Pharmaceutical
14.29 Toyama Chemical
14.30 Tsumura
14.31 UCB
14.32 Zydus Cadila

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